Table 1.
A selection of proteins detected by mass spectrometry in the three complexes.
| Complex (protein group) |
Protein |
|---|---|
| Complex I | |
| RNA polymerase | RPA2; RPA34; RPA49; RPABC1. |
| Transcription regulators | LYRIC; ILF2; SMARCA4. |
| Complex II | |
| RNA polymerase | RPB2; RPB3; RPB4; RPB7; RPB9; RPABC3; RPA2a; RPA12 a; RPAC1 a. |
| Transcription factors | Activator of basal transcription 1; TFII-I; TFIIH subunit 1; XPB helicase; TF20; TF AP-2 alpha; TF AP-4; TF Sp3; CCAAT/enhancer-binding protein-beta; CTCF; ATRX; USF1. |
| Transcription regulators | Scaffold attachment factors B1 and B2; SAFB-like transcription modulator; sex comb on midleg-like protein; splicing factor 1; SWI/SNF-related matrix-associated actin-dependent regulator; major centromere autoantigen B; far upstream element-binding protein 1; HMG20A; chromatin assembly factor 1 subunit B. |
| Histone modification enzymes | Histone-lysine N-methyltransferases EZH2, SUV39H1, and SUV39H2. |
| Complex III | |
| RNA polymerase | RPAC1. |
| Transcription regulators | Nuclear receptor coactivator 5; SWI/SNF complex subunit 2. |
| tRNA modification | Lupus La. |
| Ribosome biogenesis | 60S ribosomal protein L35a; probable ribosome biogenesis protein RPL24. |
| RNA processing | Exosome complex exonuclease MTR3; ribonuclease P protein subunit p14; U6 snRNA-associated Sm-like protein LSm8. |
| Complexes I + II + III | |
| RNA helicases | Helicases A, DDX1, DDX18, DDX24, DDX3X, DDX10, DDX47, DDX49, DDX5, DHX15. |
| Ribonucleoproteins | HnRNPs – A0, A2/B1, A3, C1/C2, F, H, H2, H3, K, L, M, Q, R, U, U-like protein 2. snRNPs E, Sm D1, Sm D2, Sm D3, U1 RNP A and A’, U5 200 kDa helicase, U1 70 kDa, U4/U6 RNP Prp31, 116 kDa U5 component, H/ACA RNP subunit 2 and 4. |
| Processing factors | Spliceosomal protein SAP 155; SF-3 subunit 1 and 2; SF-3B subunit 3 and 4; U2AF 65 kDa subunit; SF-arg/ser rich 7; SF-13A; CSTF 77 kDa subunit; CPSF subunit 6 and 7. |
a
suggested contaminants.