Table 1.

Estimates of evolutionary rates and numbers of nonsynonymous and synonymous substitutions per site (d_N/d_S) for GBV-C

Region	No.	Date range	dN/dS (SLAC)	Molecular clock	Nucleotide substitution per site per year (95% HPD)
					Constant	Logistic	Exponential
5′ UTR	108	1993–2002	NA	Relaxed exponential	4.13 × 10−3 (1.59 × 10−3–6.96 × 10−3)	4.45 × 10−3 (2.11 × 10−3–7.01 × 10−3)	5.03 × 10−3 (4.98 × 10−3–7.8 × 10−3)
				Relaxed lognormal	4.15 × 10−3 (1.64 × 10−3–7.37 × 10−3)	4.13 × 10−3 (1.73 × 10−3–6.72 × 10−3)	4.99 × 10−3 (1.79 × 10−3–7.95 × 10−3)
				Strict	2.1 × 10−3 (1.32 × 10−3–2.96 × 10−3)	2.09 × 10−3 (1.32 × 10−3–2.97 × 10−3)	1.85 × 10−3 (1.06 × 10−3–2.6 × 10−3)
E1	19	1993–1997	0.039	Relaxed exponential	5.43 × 10−2 (1.41 × 10−2–9.92 × 10−2)	1.94 × 10−2 (6.11 × 10−3–3.64 × 10−2)	2.49 × 10−2 (1.11 × 10−2–3.79 × 10−2)
				Relaxed lognormal	4.33 × 10−2 (1.39 × 10−2–7.37 × 10−2)	3.95 × 10−2 (9.44 × 10−3–7.06 × 10−2)	4.3 × 10−2 (1.48 × 10−2–7.58 × 10−2)
				Strict	3.28 × 10−2 (1.3 × 10−2–5.4 × 10−2)	3.95 × 10−2 (9.44 × 10−3–7.06 × 10−2)	3.16 × 10−2 (1.34 × 10−2–5.21 × 10−2)
E2	49	1996–1999	0.046	Relaxed exponential	2.19 × 10−2 (7.33 × 10−3–3.791 × 10−2) 2.74 × 10−2 (1.22 × 10−2–4.3 × 10−2)		2.89 × 10−2 (1.68 × 10−2–4.19 × 10−2)
				Relaxed lognormal	1.46 × 10−2 (5.19 × 10−3–2.32 × 10−2)	7.92 × 10−3 (5.52 × 10−6–1.65 × 10−2)	8.67 × 10−3 (1.49 × 10−3–1.12 × 10−2)
				Strict	3.53 × 10−3 (3.73 × 10−6–9.1 × 10−3)	2.61 × 10−3 (1.69 × 10−5–6.27 × 10−3)	3.34 × 10−3 (3.25 × 10−4–6.91 × 10−3)
NS5b	40	1993–1997	0.047	Relaxed exponential	3.55 × 10−2 (1.36 × 10−2–6.13 × 10−2)	3.58 × 10−2 (1.0 × 10−2–6.3 × 10−2)	3.24 × 10−2 (9.99 × 10−3–5.46 × 10−2)
				Relaxed lognormal	2.12 × 10−2 (7.74 × 10−3–3.55 × 10−2)	8.49 × 10−3 (1.88 × 10−5–1.94 × 10−2)	1.14 × 10−2 (2.56 × 10−3–2.14 × 10−2)
				Strict	1.52 × 10−2 (4.96 × 10−3–2.57 × 10−2)	6.99 × 10−3 (4.03 × 10−5–1.43 × 10−2)	1.02 × 10−2 (2.74 × 10−3–1.84 × 10−2)