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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Cell Metab. 2012 Apr 4;15(4):505–517. doi: 10.1016/j.cmet.2012.03.008

Figure 4. Skeletal muscle-specific YY1 knockout mice display hyperactivation of insulin/IGF signaling and increased gene expression that are insensitive to rapamycin treatment.

Figure 4

(A) and (B) Wild-type or YY1mKO mice were treated with vehicle or 2.5 mg/kg rapamycin for 14 days, fasted for 12h and then injected with vehicle or 0.6 U/kg insulin 10 min before sacrifice. Insulin signaling in skeletal muscle. (C) Wild-type or YY1mKO mice were treated with vehicle or 2.5 mg/kg rapamycin for 14 days. Gene expression in the soleus of fed mice. (D) Gene expression in C2C12 myotubes infected with scrambled shRNA or YY1 shRNA for 72h (E) Gene expression in C2C12 myotubes infected with GFP or Flag-YY1 for 48h. All values are presented as mean ± SD. n=6–10, *P<0.05, **P<0.01 and ***P<0.001. See also Figure S4.