Table 1.
Cell Surface Phenotype of Cancer Stem Cells Identified in Human Cancers
| Tumor type | CSC phenotype | References |
|---|---|---|
| AML | CD34+/CD38−, CD44+,CD34+/CD123+, CD47+ | (14, 61, 62, 64, 79) |
| ALL | CD34+/CD10−, CD34+/CD19−; | (30, 74) |
| Breast cancers | CD44+/ESA+/CD24−/Lin−, ALDH1low | (6, 41) |
| Brain tumors | CD133+, CD15+ | (105, 106) |
| Melanoma | ABCB5+, CD271+, JARID1B+, CD133+, CD20+ | (13, 37, 93, 99, 101) |
| Colorectal cancers | CD44+/EpCAM+,CD133+, ALDH1high, Lgr-5+ | (10, 32, 49, 85, 97) |
| Lung cancers | CD133+, CD133+/EpCAM+ | (36, 67) |
| Osteosarcomas | CD44+/CD105+/Stro1+ | (40) |
| Head and neck squamous cell carcinomas | CD44+/ALDHhigh | (23, 92) |
| Liver cancers | CD13+,CD90+/CD44−, CD133+, CD24+ | (68, 77, 108, 124) |
| Pancreatic cancers | CD44+/CD24+/ESA+, CD133+ | (47) |
| Prostatic cancers | CD44+/Integrin α2β1high/CD133+ | (28) |
| Skin squamous cell carcinomas | CD34+, Integrin α5β1high | (80, 103) |
| Ovarian cancers | CD44+/CD117+, CD133+ | (31, 132) |
| Bladder cancers | CD44+ | (19) |
ALDH1, aldehyde dehydrogenase-1; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; EpCAM, epithelial cell adhesion molecule; ESA, epithelial special antigen; JARID1B, the H3K4 demethylase; Lgr-5, leucine-rich-repeat containing G-protein-coupled receptor 5.