Table 2.
Effect of EEB on hepatic and serum TC, TG, HDL, and LDL levels in FRD-induced rats at week 8.
| Groups | Hepatic TG | Hepatic TC | Hepatic HDL-C | Hepatic LDL-C |
|---|---|---|---|---|
| Concentration (mg/g) | ||||
| Normal | 298.2 ± 3.6 | 26.6 ± 1.6 | 17.9 ± 0.2 | 373.4 ± 1.2 |
| FRD | 385.2 ± 7.1# | 39.5 ± 1.3# | 17.7 ± 0.8 | 457.2 ± 3.9# |
| FRD + quercetin | 359.8 ± 4.2#∗ | 38.9 ± 2.6# | 16.0 ± 0.3 | 429.7 ± 4.6# |
| FRD + rutin | 322.2 ± 7.4#∗ | 29.6 ± 1.9#∗ | 17.1 ± 0.4 | 393.1 ± 3.4#∗ |
| FRD + EEB | 310.0 ± 6.2* | 24.7 ± 1.4* | 15.7 ± 0.4* | 378.5 ± 2.0* |
| FRD + quercetin + rutin | 317.9 ± 7.3* | 27.9 ± 1.1* | 16.7 ± 0.1 | 359.8 ± 10.1* |
|
| ||||
| Groups | Plasma TG | Plasma TC | Plasma HDL-C | Plasma LDL-C |
| Concentration (mg/dL) | ||||
|
| ||||
| Normal | 124.6±1.7 | 69.0 ± 1.1 | 71.8 ± 2.5 | 126.5 ± 1.5 |
| FRD | 238.0 ± 1.1* | 94.3 ± 3.1# | 52.6 ± 1.6# | 239.5 ± 4.7# |
| FRD + quercetin | 193.5 ± 6.6#∗ | 89.0 ± 5.3# | 54.1 ± 3.7# | 235.5 ± 5.6# |
| FRD + rutin | 172.0 ± 3.3#∗ | 82.7 ± 2.8#∗ | 52.5 ± 5.3# | 211.4 ± 1.6#∗ |
| FRD + EEB | 148.5 ± 8.7#∗ | 76.6 ± 2.4#∗ | 62.8 ± 2.2#∗ | 187.5 ± 3.9#∗ |
| FRD + quercetin + rutin | 138.2 ± 6.4* | 80.5 ± 2.4#∗ | 59.4 ± 1.5#∗ | 193.2 ± 1.8#∗ |
Hyperglycemia and hyperinsulinmia in mice were induced by fructose-rich diet (FRD; 60%) for 8 weeks. The animals were randomly divided into 6 groups (n = 12), including (a) control, (b) fructose-rich diet (FRD), (c) FRD + quercetin (3 mg/kg bw), (d) FRD + rutin (11.5 mg/kg bw), (e) FRD + EEB (50 mg/kg bw), and (f) FRD + rutin + quercetin. The doses of rutin and quercetin were equivalent to those administered to the EEB administration group. Data are presented as the mean ± SEM. #Significant difference from the control group (P < 0.05). *Significant difference form the FRD group (P < 0.05). The statistics were shown by the t-test.