Table 3.
Genotype frequencies of 15 polymorphisms in glutathione S-transferases, glutathione synthesizing enzymes, and selenoproteins and simple linear regression assessing the influence of genotype on mean urine and hair Hg levels (natural log-transformed). Significant (p<0.05) β estimates (95% CI) for genotype are reported from models of urine Hg or hair Hg.
| Gene | db SNP ID | Alleles | SNP Details | n | Minor allele frequency | Urine Hg | Hair Hg |
|---|---|---|---|---|---|---|---|
|
| |||||||
| GSTP1 | rs1695 | A>G | 105 Ile>Val | 485a | 0.32 | -0.22(-0.36, -0.07) | |
| GSTP1 | rs1138272 | C>T | 114 Ala>Val | 475a | 0.08 | ||
| GCLM | rs41303970 | C>T | 5’ near gene | 481a | 0.19 | ||
| SEPP1 | rs3877899 | C>T | 234 Ala>Thr | 485a | 0.24 | ||
| SEPP1 | rs7579 | C>T | 3’ UTR | 479a | 0.28 | -0.16(-0.3, -0.02) | |
| GSTT1 | N/A | + > - | Deletion | 437a | 0.41 | -0.27(-0.52, -0.02) | |
| GPX1 | rs1050450 | C>T | 200 Pro>Leu | 223b | 0.28 | ||
| GPX4 | rs713041 | C>T | 3’ UTR | 226b | 0.45 | ||
| GCLC | rs17883901 | G>A | 5’ near gene | 230b | 0.08 | ||
| GSTM1 | N/A | -> + | Deletion | 209b | 0.32 | ||
| GGT1 | rs5751901 | T>C | intron | 251c | 0.36 | ||
| GSTM3 | rs7483 | G>A | 224 Val>Ile | 243c | 0.26 | ||
| GSS | rs3761144 | C>G | 5’ near gene | 255c | 0.40 | ||
| GSR | rs1002149 | G>T | 5’ near gene | 240c | 0.18 | ||
| GSR | rs2911678 | T>A | intron | 250c | 0.24 | ||
a
Genotyped in subjects recruited in 2009 and 2010.
b
Genotyped in subjects recruited in 2009 only.
c
Genotyped in subjects recruited in 2010 only.