Table 5.
Parameter estimates from models of natural log-transformed hair Hg levels with exposure variable (estimated mercury intake from fish consumption, ug per kg body weight per day), genotype, and genotype-by-fish Hg interactions. Models with significant genotype variables are reported. Beta coefficients (95% CI) are reported for each predictor variable. Statistically significant beta coefficients (p<0.05) are bolded.
| SNP | na | Adj. r2 | Fish Hg | Genotype | Genotype* Fish Hg |
|---|---|---|---|---|---|
|
| |||||
| Base Model | 503 | 0.19 | 3.62 (2.96, 4.28) | ||
| GSTP1-105 | 214, 216, 44 | 0.2 | 2.87 (0.95, 4.8) | -0.22 (-0.38, - 0.06) | 0.42 (-0.73, 1.57) |
| GSTP1-114 | 393, 69, 2 | 0.2 | 2.91 (0.74, 5.07) | -0.31 (-0.6, -0.03) | 0.67 (-1.05, 2.39) |
| SEPP1 3’UTR | 245, 188, 36 | 0.19 | 6.22 (4.14, 8.29) | 0.15 (-0.02, 0.32) | -1.61 (-2.82, -0.4) |
| GSS 5’ | 94, 111, 44 | 0.15 | 0.34 (-2.13, 2.81) | -0.15 (-0.35, 0.06) | 1.88 (0.44, 3.31) |
a
Number of subjects in model in each genotype group. Genotype groups are major homozygote, heterozygote, minor homozygote.