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. Author manuscript; available in PMC: 2013 Feb 17.
Published in final edited form as: Circ Res. 2012 Feb 17;110(4):638–650. doi: 10.1161/CIRCRESAHA.111.247437

Figure 2. A diagram showing miRNAs and their targets in cardiac ischemia.

Figure 2

The diagram displays the different miRNAs and their targets that are involved in cell viability, angiogenesis, fibrosis, and electrical remodeling during cardiac ischemia. Upregulation or downregulation of a specific miRNA is represented by an upward (black) or a downward (red) arrow, respectively. The change in the expression levels of target genes inversely correlates with that of the targeting miRNA and is similarly represented by an up or down arrow. All listed targets have been validated. The listed targets include: hypoxia-inducible factor 1 alpha (Hif-1α), sirtuin 1 (Sirt1), heat shock protein 20, 60, and 70 (HSP20, HSP60, HSP70), programmed cell death 4 (PDCD4), phosphatase and tensin homolog (PTEN), fas ligand (FasL), caspase 9, Rho-associated coiled-coil containing protein kinase 1 (Rock1), calmodulin kinase II delta (CAMKIIδ), BCL2-like 11 (Bim), ADP-ribosylation factor-like 2 (Arl2), B-cell CLL/lymphoma 2 (Bcl2), ephrin A3 (Ephna3), integrin, alpha 5 (ITGA5), sprouty-related, EVH1 domain containing 1 (SPRED1), GATA binding protein 2 (GATA2), p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4), cullin 2 (cul2), connexin 43 (Cx43), inward rectifier potassium channel 2 (Kir2.1).