Table 3.
Effect of Nox1 and catalase on expression of cell cycle and tumor-related genes
| Protein or gene | Fold increase or decrease
|
|
|---|---|---|
| Nox1 vs. control | Nox1/catalase vs. Nox1 | |
| Tumor-associated/tumorigenesis | ||
| Ecotropic viral integration site 2 (Evi-2) | ↑ 15, 17 | ↓ 16, 17 |
| MoMuL V-like endogenous provirus | ↑ 4.2, 14 | ↓ 4.1, 12 |
| L6 Ag | ↑ 2.3, 3.1 | ↓ 3.5, 4.3 |
| Stromelysin-3 | ↓ 1.6, 4.5 | ↑ 1, 4.8 |
| Membrane-type matrix metalloproteinase | ↓ 2.2, 6.6 | ↑ 3.6, 12 |
| Haptoglobin | ↓ 3.3, 4.2 | ↑ 1, 4.9 |
| Transin-1 (tromelysin-1) | ↓ 4.4, 10 | ↑ 1, 2.4 |
| Growth factor/cytokine | ||
| Epiregulin | ↑ 7.7, 11 | ↓ 6.0, 7.6 |
| Hepatoma transmembrane kinase ligand | ↑ 3.7, 8.3 | ↓ 2.0, 17 |
| New member PDGF/VEGT family growth factors | ↓ 2.2, 2.9 | ↑ 13, 15 |
| Preproendothelin-1 (ET-1) | ↓ 3.0, 6.6 | ↑ 1, 3.7 |
| Signaling | ||
| MAPKK6 | ↑ 3.2, 7.7 | |
| Calcineurin catalytic subunit (PP2B) | ↑ 2.1, 2.5 | ↓ 1, 2.8 |
| Zipper protein kinase | ↑ 1.3, 3.4 | |
| Protein-tyrosine kinase substrate p36 | ↑ 1.5, 3.3 | ↓ 2.5, 3.3 |
| pre-PDGF receptor | ↓ 2.5, 3.7 | ↑ 2.1, 5.2 |
| Serum-inducible kinase | ↓ 3.0, 6.8 | ↑ 3.0, 5.2 |
| Cell cycle | ||
| Cyclin-like protein (Cyl-1) | ↑ 2.5, 3.2 | ↓ 3.8, 7.2 |
| Cyclin G | ↑ 2.1, 3.8 | ↓ 1.6, 4.2 |
mRNA levels were evaluated using a DNA microarray, as described in Materials and Methods. Fold increase (↑) or decrease (↓) in mRNA level is indicated. The values of two independent experiments are shown.