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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Neurotoxicol Teratol. 2012 Jan 15;34(2):221–231. doi: 10.1016/j.ntt.2012.01.001

Table 5.

Summary of Significant Effects Compared to Controls Across the Test Period

Arsenic
Exposure
Group		 Effects in Neonates Effects in
Juveniles		 Effects in Adults
8 ppm

  1. Impaired righting reflex

  2. Reduced acoustic startle on PND13

  3. Reduced motor activity on PND 13 & 17

  4. Increased aberrant behaviors from PND17–21

  1. None

  1. Decreased grip strength in males and females

  2. Increased RR lever run rates and earned food in males

  3. Increased Go/No Go false alarms in males

  4. Reduced Go/No Go ITI responses
25 ppm

  1. Impaired righting reflex

  2. Reduced acoustic startle on PND13 & 21

  3. Reduced motor activity on PND 13 & 17

  4. Increased aberrant behaviors from PND19–21

  1. None

  1. Decreased grip strength in males and females

  2. Reduced Go/No Go ITI responses
80 ppm

  1. Impaired righting reflex

  2. Reduced acoustic startle on PND13 & 17

  3. Reduced motor activity on PND 13 & 17

  4. Increased aberrant behaviors from PND19–21

  1. None

  1. Decreased grip strength in males and females

  2. Increased RR lever run rates and earned food in males

  3. Reduced Go/No Go ITI responses