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. Author manuscript; available in PMC: 2013 Apr 2.
Published in final edited form as: Mol Pharm. 2012 Mar 19;9(4):914–921. doi: 10.1021/mp200458e

Fig. 1.5.

Fig. 1.5

Three simulations where chemotherapy is applied first (0.2) using three different penalties for cells that are susceptible to the p53 vaccine. Application of chemotherapy results in a strong selection force for tumour cells that are resistant. After 25 time steps the chemotherapy resistant population has managed to grow and overtake the other two but significant amounts of sensitive and p53 vaccine resistant remain. Left 0.2. Centre 0.3. Right 0.4. Bottom The average tumour fitness under the three different scenarios.