Figure 4. Differential risk allele frequencies in the East Asian populations for 12 common diseases, compared with the frequencies in the European.

We identified 12 common diseases with five or more independent cross-ethnic risk alleles from Varimed. Similar with Figure 3, we plotted the average increased RAFs in the East Asia regions in the HGDP for each of 12 diseases, against the null distributions of frequency-matched control genomic alleles and risk alleles for other diseases. We ordered these 12 diseases by the increased RAF for a direct comparison. T2D was the only disease showing significantly lower RAFs in the East Asian populations. Two-side p values were calculated by comparing dotted vertical lines against the null distributions of frequency-matched control genomic alleles and risk alleles of other diseases. SNPs used in each figure were summarized in Table S4.