Figure 2. Phenotypic Resistance Profiles in Patients Who Did Not Achieve SVR with a TVR-based Regimen.

Data from ADVANCE include only the T12PR arm and data from REALIZE include pooled TVR arms. Higher-level resistance (red) is defined as >25-fold increase in IC₅₀ and lower-level resistance (yellow) is defined as 3- to 25-fold increase in IC₅₀ from wild-type. Grey (n/a) indicates patients with no sequence data available due to HCV RNA levels below the LOD of the sequencing assay or lost-to-follow-up.