Table 2. Relationships between BRCA1-IRIS level and marker expression and tumor characteristics in Her2+ and TN/BL breast cancer tumor samples.
| Her2+ (n = 32) | TN/BL (n = 72) | |||
| IRIS-positive | IRIS-negative | IRIS-positive | IRIS-negative | |
| Characteristics | (%) | (%) | (%) | (%) |
| (n = 26) | (n = 6) | (n = 63) | (n = 9) | |
| AKT-positive (3+ and 2+) | 19 (73) | 3 (50) | 54 (86) | 7 (78) |
| AKT-positive (1+ and 0) | 7 (27) | 3 (50) | 9 (14) | 2 (22) |
| ar | 0.752 | 0.002 | 0.748 | 0.009 |
| b p-value | 0.000009 | 0.621 | 0.00043 | 0.492 |
| Surv-positive (3+ and 2+) | 26 (100) | 5 (83) | 53 (84) | 7 (78) |
| Surv-positive (1+ and 0) | 0 (0) | 1 (17) | 10 (16) | 2 (22) |
| ar | 0.859 | 0.03 | 0.834 | 0.008 |
| b p-value | 0.000001 | 0.822 | 0.0038 | 0.432 |
| Tumor Grade (as modified nuclear grade) | ||||
| 1 | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| 2 | 12 (46) | 6 (100) | 25 (40) | 9 (100) |
| 3 | 14 (53) | 0 (0) | 38 (60) | 0 (0) |
| c p-value | 0.0221 | 0.0426 | 0.0152 | 0.667 |
| Tumor Stage | ||||
| In situ | 0 (0) | 0 (0) | 3 (5) | 0 (0) |
| Localized | 11 (44) | 3 (50) | 35 (56) | 6 (67) |
| Lymph-node | 8 (31) | 3 (50) | 20 (32) | 3 (33) |
| Distant Mets | 7 (25) | 0 (0) | 5 (8) | 0 (0) |
| c p-value | 0.0201 | 0.617 | 0.0184 | 0.0421 |
a
Spearman rank coefficient test correlation (r),
b
Spearman rank coefficient test p-value,
c
To compare multiple groups with one control group, analysis of variance (ANOVA) was used.
p-values (two-sided) <0.05 were considered statistically significant.