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. 2012 Apr 12;7(4):e34971. doi: 10.1371/journal.pone.0034971

Figure 6. CXCL12 has direct effect on worm growth in vitro.

Figure 6

Length of filariae (mm) was measured before and after 5 days of in vitro culture. Groups of filariae were constituted and treated with either CXCL12 (1 nM, 10 nM), Chalcone C04 (C04, 1 µM, 10 µM), AMD3100 (AMD, 25, 50 µg/ml) or IL-5 (5 ng/ml). Treatments were added daily to wells containing two filariae in 1 ml, as detailed in Materials and Method. Length increase was expressed as median ± interquartile range of 30 filariae for control group (Ctrl, medium only), 20 for other groups, and 10 for the IL-5 treated group. The differences between treatments were analysed by a non parametric Kruskall-wallis test followed by Dunn's multiple comparison test, with control group as reference. “*” marks significant differences between treated filariae and the control group (*p<0.05).