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. 2012 Apr 12;7(4):e34658. doi: 10.1371/journal.pone.0034658

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Greenall et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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LMH 85 and LMH 87 were converted into scFv format and tested for their ability to block HGF/SF stimulation of the c-MET receptor. A549 cells were treated with either scFv 85 or scFv 87 and then HGF/SF added. A vehicle control without HGF/SF was included. Whole cell lysates were then probed for total c-MET (upper panel), phosphorylated c-MET (Tyr1234/1235; middle panel) and pan-actin to control for loading (bottom panel). The phosphorylated c-MET blot shows that scFv 85, but not scFv 87, inhibited HGF/SF stimulation of c-MET.