Table 4. Base Case Results for the Alternative Strategies for Cost, QALY Gained and ICER.
Cost ($) | Utility (QALY) | ICER | |||||||
Cohort | RT | NT+RT | TMZ+RT | RT | NT+RT | TMZ+RT | TMZ+RT VS. RT | TMZ+RT VS. RT+NT | NT+RT VS. RT |
Overall cohort | 7,234.0 | 8,655.9 | 32,562.4 | 0.80 | 0.84 | 1.09 | 87,940.6 | 94,968.3 | 39,185.1 |
Subgroups: | |||||||||
MGMT methylated | 7,753.3 | 9,500.0 | 37,598.2 | 1.12 | 1.27 | 1.47 | 7,015.3 | 141,144.1 | 11,237.3 |
MGMT unmethylated | 7,206.6 | 8,540.0 | 31,319.8 | 0.76 | 0.79 | 0.87 | 19,188.7 | 299,673.0 | 46,454.0 |
Complete resection | 7,677.3 | 9,678.5 | 34,644.4 | 0.94 | 1.02 | 1.27 | 6,898.8 | 100,108.0 | 26,207.2 |
Partial resection | 7,267.0 | 8,703.3 | 28,193.7 | 0.80 | 0.84 | 0.96 | 11,180.8 | 168,668.1 | 35,537.2 |
Biopsy only | 6,074.1 | 6,855.1 | 25,598.8 | 0.57 | 0.61 | 0.73 | 10,741.1 | 157,802.5 | 23,883.3 |
Age <50 years | 7,672.3 | 9,900.1 | 29,351.4 | 0.87 | 0.97 | 1.16 | 6,125.4 | 103,010.5 | 20,995.6 |
Age 50∼60 years | 7,374.4 | 8,866.0 | 32,182.4 | 0.82 | 0.86 | 1.02 | 10,609.3 | 155,206.9 | 33,419.7 |
Age >60 years | 6,990.5 | 8,261.0 | 26,388.8 | 0.78 | 0.79 | 0.86 | 21,434.9 | 279,507.5 | 120,317.5 |