Table 2. Aqueous cytokine concentrations comparing TAU, IU, and Controls.
|
TAU n=10 |
IU n=15 |
Controls n=23 |
|
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---|---|---|---|---|---|---|---|---|---|---|
Cytokines | Median | Range (%) | Mean±Std error | Median | Range (%) | Mean±Std error | Median | Range (%) | Mean±Std error | Sensitivity |
IL-2 |
3.4* |
0–5 (9/10) |
3.0±0.4 |
0.0‡ |
0–9 (2/15) |
0.9±0.6 |
2.8 |
0–17 (17/23) |
3.4±0.8 |
1.6 |
IFN-γ |
26.3 |
0–219 (8/10) |
66.9±24.5 |
10.9 |
0–71 (8/15) |
17.3±5.9 |
12.7 |
0–91 (12/21) |
15.6±4.5 |
6.4 |
IL-6 |
80.7† |
2–2018 (7/9) |
470.4±276.8 |
7.0‡ |
1–68 (11/13) |
21.8±6.1 |
2.2 |
0–14 (8/22) |
3.4±0.6 |
2.6 |
IL-10 |
1.9 |
0–4 (9/10) |
2.0±0.4 |
0.3 |
0–8 (7/15) |
1.3±0.6 |
1.5 |
0–5 (20/23) |
1.7±0.2 |
0.3 |
IL-12 |
7.3* |
2–15 (7/10) |
7.1±1.4 |
0.0‡ |
0–2 (0/15) |
0.5±0.2 |
8.7 |
0–27 (19/23) |
8.7±1.3 |
3.5 |
TNF-α |
12.1* |
1–23 (8/10) |
12.0±2.6 |
0.0‡ |
0–4 (0/14) |
0.5±0.3 |
9.6 |
0–34 (17/23) |
9.8±1.7 |
6.0 |
CCL2 |
380.8 |
158–1124 (10/10) |
485.3±98.8 |
531.3‡ |
47–1354 (15/15) |
604.7±113.9 |
180.9 |
32–962 (23/23) |
252.5±50.5 |
1.1 |
CXCL8 |
61.7† |
4–538 (10/10) |
104.9±50.3 |
17.6‡ |
4–135 (15/15) |
39.6±12.1 |
3.0 |
1–20 (21/22) |
4.8±1.0 |
1.0 |
CXCL9 |
4790.6*† |
81–51068 (9/9) |
17115.9±6393.3 |
0.0 |
0–401 (5/11) |
102.7±42.6 |
63.0 |
0–834 (19/21) |
153.3±44.8 |
1.2 |
CXCL10 |
15621.1† |
41–114173 (10/10) |
49766.9±17640.0 |
631.6 |
0–107547 (11/15) |
18632.6±9548.9 |
56.3 |
0–766 (20/22) |
147.9±45.7 |
6.1 |
IL-9 | 8.26† | 4–18 (9/9) | 8.8±1.4 | 15.6‡ | 0–45 (9/10) | 16.5±4.0 | 5.5 | 0–11 (17/19) | 5.5±0.6 | 2.5 |
TAU=uveitis associated with tuberculosis, IU: idiopathic uveitis; IFN-γ: interferon-gamma; TNF-α: tumor necrosis factor-alpha, CCL2: MCP-1, monocyte chemotactic protein-1; CXCL8 (IL-8, interleukin-8); CXCL9 (MIG, monokine induced by interferon-gamma); CXCL10 (IP-10, interferon-gamma-induced protein 10). Cytokines level at pg/ml. * p<0.05, for TAU versus IU; †p<0.05, for TAU versus controls; ‡ p<0.05, for IU versus controls by Mann-Whitney U test with Bonferroni correction.