Table 1.

TTR binding selectivity in human plasma of NSAIDs that inhibit amyloid formation in vitro

Compound	Molar eq bound at 10.8 μM	Maximal therapeutic concentration, μM	Molar eq bound at max. therapeutic conc.
1 Flufenamic acid	0.20  ± 0.02	54	0.59  ± 0.05
2 Mefenamic acid	0.20  ± 0.03	21	0.20  ± 0.03
3 Meclofenamic acid	0.14  ± 0.02	15	NA
4 Diflunisal	0.13  ± 0.02	224	0.86  ± 0.12
5 Diclofenac	0.04  ± 0.01	5	NA
6 Flurbiprofen	No binding	62	No binding
7 Fenoprofen	No binding	96	No binding
8 Indomethacin	No binding	6	NA

NA, not applicable.