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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Dec 7;36(5):826–834. doi: 10.1111/j.1530-0277.2011.01678.x

Figure 1.

Figure 1

Lytic Activity is decreased in mice which have consumed ethanol for one week and increased in mice which have consumed ethanol for eight weeks. C57BL/6 mice were acclimated to ethanol for one week and maintained on 20% ethanol thereafter. Splenic NK lytic activity was determined by chromium release assay after overnight culture with 200 units/ml IL-2 or 10 micrograms/ml CpG A using the NK sensitive cell line YAC-1. The data on the Y-Axis indicate Lytic Units per 1 × 106 effector cells. Lytic activity was significantly reduced (p < 0.0035 for IL2; p<0.0001 for CpG); data are average of 4 experiment with 5 mice in each experiment) in ethanol-consuming groups relative to water controls after one week of ethanol consumption (A). Lytic activity was significantly increased (p 0.0327 for IL2, 0.0041 for CpG) in ethanol-consuming groups relative to water controls after eight weeks of ethanol consumption (B).