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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Mech Ageing Dev. 2011 Nov 3;133(4):118–126. doi: 10.1016/j.mad.2011.10.009

Figure 2. Heavy mutation load limits the lifespan and health-span of mutator mice.

Figure 2

Due to the dramatically reduced lifespan of these mutator mice, it has not been established whether they age more rapidly than do wild type mice. WT=wild-type; Polee/e=homozygous exonuclease deficient pol ε; Pold1e/e=homozygous exonuclease deficient pol δ. Data are reported in Albertson et. al.