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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Arthritis Rheum. 2012 May;64(5):1620–1631. doi: 10.1002/art.33485

Figure 4.

Figure 4

NGAL worsens kidney injury in NTN. 129/SvJ mice received nephrotoxic serum, and in addition received 250 μg of NGAL (“NTN+NGAL”; n=10) or PBS (“NTN alone”; n=10) intravenously on d6. An additional control group of mice was immunized with rabbit IgG as above but received injections of PBS on d5, and 250 μg NGAL on d6 (“NGAL alone”; n=10). (A) Kidney from a NGAL alone mouse (PAS; 20×) showing preserved glomeruli and tubules. (B) Kidney from a NGAL alone mouse (PAS; 60×) showing 2 normocellular glomeruli without PAS+ deposits. (C) Kidney from a NTN alone mouse (PAS; 20×) showing mildly enlarged glomeruli with patchy segmental PAS+ deposits. (D) Kidney from a NTN alone mouse (PAS; 60×) showing 2 glomeruli, one of which shows moderate PAS+ deposition and endocapillary proliferation. (E) Kidney from a NTN+NGAL mouse (PAS; 20×) showing enlarged glomeruli with prominent PAS+ deposits and patchy dilatation of tubules with proteinaceous casts. (F) Kidney from a NTN+NGAL mouse (PAS; 60×) showing 3 glomeruli globally expanded by abundant PAS+ deposits, accompanied by moderate segmental endocapillary proliferation. Also seen are mildly dilated distal tubules with proteinaceous casts. Selected kidney sections are representative of the histology in each group.