. 2011 Mar 25;42(5):1529–1539. doi: 10.1007/s00726-011-0883-5

Table 1.

Clinical studies with diabetes and complications

Article	Subjects	Duration	Dose (/day)	Endpoint	Result
Diabetes
Franconi et al. (1995)	IDDM patients (n = 39)	90 days	1.5 g	Glucose metabolism	NC
Elizarova and Nedosugova (1996)	IDDM patients (n = 10)	30 days	1 g	Glucose metabolism	Improved
Elizarova and Nedosugova (1996)	IDDM patients (n = 10)	30 days	1 g	Triglyceride	Decreased
Chauncey et al. (2003)	NIDDM patients (n = 32)	4 months	3 g	HbA1c	NC
Chauncey et al. (2003)	NIDDM patients (n = 32)	4 months	3 g	Plasma lipid peroxide level	NC
Brons et al. (2004)	Overweight non-diabetic men (n = 20)	8 weeks	1.5 g	Insulin secretion	NC
Brons et al. (2004)	Overweight non-diabetic men (n = 20)	8 weeks	1.5 g	Plasma lipid level	NC
Xiao et al. (2008)	Overweight non-diabetic men (n = 6).	2 weeks	3 g	Insulin sensitivity impaired by 48-h infusion of intravenous lipid	Improved
Xiao et al. (2008)	Overweight non-diabetic men (n = 6).	2 weeks	3 g	Lipid peroxidation products	Decreased
Complications
Nakamura et al. (1999)	NIDDM patients with microalbuminemia (n = 10 each group)	12 months	3 g	Microalbuminemia	NC
Nakamura et al. (1999)	NIDDM patients with microalbuminemia (n = 10 each group)	12 months	3 g	Biomarkers for fibrosis	NC
Moloney et al. (2010)	IDDM patients (n = 9)	2 weeks	1.5 g	Hyperglycemia	NC
Moloney et al. (2010)	IDDM patients (n = 9)	2 weeks	1.5 g	Endothelium-dependent reaction	Improved

NC Not changed