Figure 4.

Two vascular cell types display COX-1-IR. Bright-field photomicrograph from an LPS-treated rat (2 μg/kg, i.v.) showing two distinct labeling patterns of vascular COX-1-immunoreactive cells. One, which we interpret as representing nuclear/perinuclear labeling of endothelial cells (arrows), appears as relatively homogeneous staining of round profiles 7–9 μm in diameter. The second, of presumed PVCs, appears as dense perinuclear staining associated with patches of reaction product in the cytoplasm. Scale bar, 10 μm.