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. 2012 Apr 14;18(14):1579–1589. doi: 10.3748/wjg.v18.i14.1579

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Proposed model for mode of action of epithelial Pten signalling in intestinal epithelial determination and specification of enteroendocrine progenitor cell fate. Epithelial Pten signalling is not essential for maintenance or determination of the secretory precursor. Pten represses specification of glucose-dependent insulinotropic peptide (GIP)-expressing cells by maintaining FoxO1 in the nucleus. GHR: Ghrelin; GRP: Gastrin-releasing peptide; SCT: Secretin; CCK: Cholecystokinin; SST: Somatostatin; GIP: Glucose-dependent insulinotropic peptide; CgA: Chromogranin A.