Table 2.
Summary odds ratios and 95% CI in the vitamin D receptor gene
| SNP | Model | Total No. cases | Total No. controls | OR (95% CI)1 | P value2 | P value3 |
| Cdx-2 | Codominant (CC vs cc) | 152/1561 | 146/1820 | 1.25 (0.98-1.59) | 0.07 | 0.26 |
| Codominant (Cc vs cc) | 926/2487 | 982/2802 | 1.09 (0.97-1.22) | 0.15 | 0.64 | |
| Codominant (C vs C) | 1230/4048 | 1279/4622 | 1.10 (1.01-1.21) | 0.03 | 0.47 | |
| Dominant (CC + Cc vs cc) | 1078/1561 | 1208/1820 | 0.98 (0.88-1.09) | 0.72 | < 0.001 | |
| Recessive (CC vs Cc + cc) | 152/2487 | 146/2802 | 1.22 (0.96-1.54) | 0.10 | 0.23 | |
| FokI | Codominant (ff vs FF) | 1844/5068 | 2377/5982 | 0.94 (0.87-1.01) | 0.09 | 0.001 |
| Codominant (Ff vs FF) | 6189/11 257 | 7583/13 565 | 0.98 (0.93-1.03) | 0.34 | 0.001 | |
| Codominant (f vs F) | 9867/16 320 | 12 190/19 329 | 0.97 (0.94-1.00) | 0.07 | < 0.001 | |
| Dominant (ff + Ff vs FF) | 8033/5068 | 9960/5982 | 0.96 (0.92-1.01) | 0.15 | < 0.001 | |
| Recessive (ff vs FF + Ff) | 1844/11 257 | 2377/13 565 | 0.95 (0.89-1.02) | 0.13 | 0.01 | |
| BsmI | Codominant (BB vs bb) | 1512/3838 | 1817/4122 | 0.87 (0.80-0.94) | < 0.001 | 0.65 |
| Codominant (Bb vs bb) | 4733/8571 | 5303/9425 | 0.94 (0.88-0.99) | 0.03 | 0.64 | |
| Codominant (B vs b) | 7757/12 409 | 8937/13 577 | 0.93 (0.90-0.97) | < 0.001 | 0.85 | |
| Dominant (BB + Bb vs bb) | 6245/3838 | 7120/4122 | 0.92 (0.87-0.97) | 0.003 | 0.84 | |
| Recessive (BB vs Bb + bb) | 1512/8571 | 1817/9425 | 0.90 (0.84-0.97) | 0.006 | 0.28 | |
| ApaI | Codominant (AA vs aa) | 748/578 | 1004/603 | 0.85 (0.73-0.99) | 0.03 | 0.06 |
| Codominant (Aa vs aa) | 1378/1956 | 1593/2196 | 0.91 (0.79-1.04) | 0.18 | 0.39 | |
| Codominant (A vs a) | 2944/2534 | 3601/2799 | 0.92 (0.85-0.99) | 0.02 | 0.04 | |
| Dominant (AA + Aa vs Aa) | 2161/578 | 2597/603 | 0.89 (0.78-1.01) | 0.07 | 0.12 | |
| Recessive (AA vs Aa + aa) | 783/1956 | 1004/2196 | 0.89 (0.80-1.00) | 0.05 | 0.21 | |
| TaqI | Codominant (tt vs TT) | 382/1112 | 398/1320 | 1.05 (0.89-1.24) | 0.58 | 0.07 |
| Codominant (Tt vs TT) | 1086/2198 | 1298/2618 | 0.93 (0.83-1.05) | 0.23 | 0.30 | |
| Codominant (t vs T) | 1850/3310 | 2098/3938 | 0.99 (0.92-1.08) | 0.86 | 0.10 | |
| Dominant (tt + Tt vs TT) | 1468/1112 | 1696/1320 | 0.95 (0.85-1.07) | 0.42 | 0.37 | |
| Recessive (tt vs Tt + TT) | 382/2198 | 398/2618 | 1.07 (0.92-1.25) | 0.38 | 0.01 |
1
Based on fixed effects model;
2
Test for overall effect;
3
Test for heterogeneity. OR: Odds ratios.