FIG. 2.

Quantification of post-traumatic blood–brain barrier dysfunction in C57BL/6 wild-type (n=11) and Rag1^−/− mice (n=14) at 4 h after closed head injury or sham surgery. Evans blue extravasation into the injured (left) and non-injured (right) brain hemispheres was quantified by fluorospectrophotometry, as outlined in the methods section. Data are presented as medians±standard deviation; (*p<0.05 for left versus right hemisphere in head-injured mice, and for left hemisphere in head-injured versus sham-operated mice in both groups; TBI, traumatic brain injury).