FIG. 2.

Caffeic acid phenethyl ester (CAPE) does not improve neurobehavioral outcome in injured rats. (A) Time line of drug administration and behavioral assessments. Rats (n=10/group) were injured then injected with either CAPE (10 mg/kg) or an equal volume of vehicle 30 min post-injury. Rats received daily injections for the first 5 days post-injury. (B–D) When tested for their motor function, rats treated with CAPE did not perform significantly differently from vehicle-treated rats as tested using a (B) beam balance task, or in the number of (C) ipsilateral or (D) contralateral foot faults. (E) When tested for spatial learning and memory on days 14–18 and 21–24 post-injury, rats treated with CAPE had learning curves that were not significantly different than those treated with vehicle. Data are presented as the mean±standard error of the mean.