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. 2011 Dec 27;287(8):5891–5897. doi: 10.1074/jbc.M111.311811

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Characterization of mutants 4 (His/Ser+Asp/Ser) and 9 (His/Tyr) for in vivo PK profile. Pharmacokinetics of the native IgG1 and two mutants were characterized by single IV bolus dose in SCID beige mice using 2 or 25 mg/kg of the IgG1. Serum samples were collected at various time points up to 21 days post-dose and analyzed for the IgG1, Mutant 4, or Mutant 9 concentrations that were measured using an ELISA method as described under “Experimental Procedures.” Each data point was obtained using 3 mice. These results showed similar PK profiles between the native IgG1 and its mutants.