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. 2011 Aug 29;31(15):1975–1987. doi: 10.1038/onc.2011.372

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Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Model of RASSF1A regulation during mitosis. At the early mitosis, APC/C^Cdc20 is sequentially inhibited by Emi1 and RASSF1A. RASSF1A is subsequently phosphorylated by Aurora A and Aurora B accumulating during mitosis. This phosphorylation turns RASSF1A from an inhibitor to a substrate of APC/C^Cdc20. As a result, RASSF1A is ubiquitinated and targeted for proteasomal degradation. Consequently, the partially activated APC/C^Cdc20 can ubiquitinate Cyclin A. The whole process occurs before passing the spindle checkpoint.