Table 4.

AβPP Isoform Expression Ratios

	Superior Frontal Gyrus			Cerebellum
	ND	AD		ND	AD
% AβPP695	15.7% ± 2.9	8.3% ± 1.8	p=0.051	24.9% ± 4.1	20.9% ± 4.1	p=0.41
% AβPP751	30.0% ± 5.6	30.9% ± 5.7	p=0.92	21.4% ± 5.4	21.1% ± 4.0	p=0.86
% AβPP770	1.9% ± 0.3	3.3% ± 0.4	p=0.013	1.8% ± 0.3	1.3% ± 0.2	p=0.12
% AβPP-KPI	32.0% ± 5.8	34.2% ± 6.0	p=0.80	23.2% ± 5.3	22.5% ± 4.1	p=0.80
AβPP695 / AβPP-KPI	0.50 ± 0.04	0.22 ± 0.02	p≪0.001	1.21 ± 0.14	0.94 ± 0.09	p=0.12

% Total AβPP ± SEM

AβPP-KPI = AβPP751 + AβPP770

p-values in from two-tailed Student’s t-test with adjustment for unequal variance where necessary.