Figure 3.

Effect of Minority Variants and Antiretroviral Therapy Adherence on Virologic Failure

Abbreviations: MV, Minority Variants; VF, Virologic Failure

^aMultivariate Cox regression analysis included adherence, ethnicity, baseline CD4 cell count, and HIV-1 RNA levels.

^bNumber of participants with virologic failure / total participants categorized by those with and without detectable minority variants. Participant numbers include additional virologic failure cases from the case-control and case cohort studies^20–23.

Cox proportional hazard rations shown are in comparison to those without minority variants unless otherwise noted. Three studies contributed to the adherence analysis^{14, 19, 20}. Analysis of MV copy numbers excluded three studies using assays that could not provide a percentage^{17, 21, 22}. For the MV 1% threshold analysis, one study was excluded due to a limit of detection of 2% for the assay¹⁷ and only NNRT1 MVs were evaluated for two studies due to incompatible limits of detection fon the NRTI MVs^{21, 22}. Four studies were excluded from the 0.5% threshold analysis due to higher limits of MV detection^{14, 17, 21, 22}.