Fig. 1.
Reconstitution of recipient peritoneal cavity (PerC) B cells after cotransfer of bulk bone marrow (BM) and PerC. Donor cells (3 × 106 BALB/c BM and 3 × 106 CB.17 PerC) were injected i.v. to sublethally irradiated RAG1−/− recipients. Two months after transfer, B-cell reconstitution was analyzed in recipient PerC as shown. Donor BM (IgMa) cells readily reconstituted B-2 (IgDhi, IgMlo) and B-1b (IgDlo, IgMhi, CD5–) in PerC of recipient mice. In contrast, donor PerC (IgMb) cells mainly reconstituted B-1a (IgDlo, IgMhi, and CD5+) and B-1b.