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Depolarizing influence of TWIK1 in pancreatic β cells. (A) In pancreatic islets, TWIK1 is immunodetected in insulin-expressing B cells. Cells that do not express TWIK1 are glucagon- or somatostatin-positive cells. (Scale bar, 5 μM.) (B) Membrane potential (Em) of β cells primary-cultured from TWIK1−/− or control (WT) mice in various external glucose concentrations.
