Fig. 3.

STPP polymorphism mediates apparent relationship between 5-HTTLPR and anxiety and depressive symptoms. Bootstrap mediation analyses indicate that the influence of 5-HTTLPR on trait anxiety (A) and depressive symptoms (B) is mediated by the STPP. Path a shows the estimated coefficient of the relationship between the 5-HTTLPR and STPP. Path b shows the coefficient for the relationship between STPP and each self-report measure. Paths c and c′ show coefficients for the total (dashed line) and direct (solid line) effects of 5-HTTLPR on each measure. All coefficients are unstandardized, SEM in parentheses. **P < 0.01, ***P < 0.001 (Mediation Effects: STAI-T: P = 0.0011; BDI-II: P = 0.0017).