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. 2012 Mar 19;109(14):5405–5410. doi: 10.1073/pnas.1118801109

Fig. 3.

Fig. 3.

Limited segmental flexibility of CD4. Stereoview of CD4 in the TCR–pMHC–CD4 complex overlayed onto CD4 in unbound form (PDB ID code 1WIO) (15). The CD4 molecules were superposed through the D3 domain. Bound CD4 is pink, and unbound CD4 is cyan. The D1–D2 junction shows no variability, whereas the D2–D3 and D3–D4 junctions display angular differences of 11° and 4°, respectively. The pink and cyan spheres mark the centers of mass of the D1 and D4 domains in the bound and unbound CD4 structures, respectively. The purple spheres mark the D2–D3 and D3–D4 junctions.