Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Constant-force records reveal misfolded states. (A) High-resolution extension records at a constant force of 9.5 pN reveal frequent transient spikes down from state U, reaching two different extension values that represent off-pathway intermediates (labeled M1, M2). (Inset) Magnified view of data in blue square. (B) Transitions from U to a longer-lived off-pathway state (M3) are observed very rarely. Force = 9.2 pN.
