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Mfn2 ablation causes ER stress and JNK activation. (A–B) ER stress markers were evaluated in liver from C and L-KO mice (A) and in skeletal muscle from C and KO mice (B). (C–G) Western blot analysis of pJNK was performed in liver of C and L-KO mice (C), skeletal muscle from C and KO mice (E), and L6E9 myotubes (F). Ser 307 phosphorylation of IRS1 was analyzed in livers from C and L-KO mice (D) and L6E9 myotubes (G).
