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Mutant SOD1 human spinal cords show distinct skein-like intracellular inclusions immunoreactive with C4F6. All SOD1A4V cases examined (Upper panels) show skein-like inclusions in motor neurons. Non-SOD1 fALS, sporadic ALS, other neurological diseases, and nondiseased controls (Lower panels) show diffuse staining and do not exhibit skein-like inclusions. (Scale bar: 50 μm.)
