Fig. 6.

Blocking PK2 actions improved functional behavioral outcome after stroke. (A) Diagram of the experimental design for behavior studies. A single dose (75 mg/kg) of PK2 receptor antagonist was given 30 min after stroke, and neurological tests were performed on days 2, 4, 7, 14, and 21 d after reperfusion. Baseline data were collected 7 d before stroke. PKR-A significantly improved neurological outcome in the whisker test (B) and in the forelimb flexion test (C). Error bars represent SEM. n = 10–12. *P < 0.05, **P < 0.01, two-way ANOVA with Bonferroni's post hoc test.