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. 2012 Mar 15;109(14):5399–5404. doi: 10.1073/pnas.1120606109

Fig. 1.

Fig. 1.

Structure of the TIGIT/PVR complex. (A) Side view of the TIGIT IgV domain (gold) in complex with the PVR D1 domain (blue; sugar moieties in red). The TIGIT/PVR interface shows a conserved lock-and-key (B) interaction between the two molecules. The “lock” is formed by the AX6G motif, and the “key” is formed by the corresponding T(Y/F)P motif on the neighboring molecule. The “key” residues Tyr113 and Phe128 in the conserved TIGIT motif TYP and the PVR motif TFP are labeled. Both (V/I)(S/T)Q motifs are also located in the complex interface. (C) Detailed view of the “key” formed by Tyr113 in TIGIT and the lock formed by the AX6G motif of PVR. (D) Detailed view of the “key” formed by Phe128 on PVR and of the lock formed by the AX6G motif of TIGIT.