Figure 1.

Large cell neuroendocrine carcinoma of the cervix. a) Liquid-based Pap specimen showing clusters of tumor cells. Notice a mitotic figure in the bottom half of the cluster (Pap stain, original magnification ×400). b) Tumor with a solid and trabecular architecture (hematoxylin and eosin, original magnification ×100). c) Large tumor cells with a high nuclear-to-cytoplasmic ratio, small nucleoli, finely granular chromatin and numerous mitotic figures, including atypical mitoses (arrow) (hematoxylin and eosin, original magnification ×400). d) Tumor cells with diffuse and strong positive immunoreactivity for cytokeratin AE1/AE3 (immunostain for cytokeratin AE1/AE3, original magnification ×100). e) Positive immunostaining of the tumor for chromogranin (immunostain for chromogranin, original magnification ×200). f) Positive immunostaining of the tumor for synaptophysin (immunostain for synaptophysin, original magnification ×200).