The process-based model presented here integrates Disner, Beevers, Haigh, and Beck’s (2011) Integrated Cognitive Neurobiological Model of Depression with Haigh and Beck’s (2011) Generic Model. The model represents the sequence of events that leads to depressive and/or anxious symptomatology, highlighting the contribution of transdiagnostic cognitive biases in attention, processing, and memory, as well as corresponding neurobiological processes.