Table 3.
Efficacy of Dronabinol: Selected Food Consumption and Body Weight Measures
| PBO | Days 1–8 DRON |
PBO | Days 9–16 DRON |
|||
|---|---|---|---|---|---|---|
| Meana (S.E.M) |
Meana (S.E.M) |
Fb | Meana (S.E.M) |
Meana (S.E.M) |
Fb | |
| Total Daily Caloric Intake (kcal) |
3227.6 (145.3) |
3579.9 (212.8) |
16.0*⇑ | 3240.8 (87.5) |
3216.2 (215.3) |
0.1 |
| Daily Intake: | ||||||
| Morning (kcal) | 764.8 (55.2) |
669.4 (81.5) |
9.7*⇓ | 728.1 (71.5) |
679.3 (104.2) |
2.5 |
| Afternoon (kcal) | 955.2 (95.6) |
1120.8 (120.0) |
5.3 | 1048.4 (119.6) |
1015.9 (166.7) |
0.2 |
| Evening (kcal) | 1501.8 (164.8) |
1749.6 (157.2) |
11.4*⇑ | 1439.9 (169.7) |
1484.4 (211.7) |
0.4 |
| Daily Fat Intake (gm) | 112.9 (5.9) |
130.6 (12.4) |
12.6*⇑ | 113.9 (5.6) |
112.2 (12.1) |
0.1 |
| Daily Carbohydrate Intake (gm) | 456.2 (32.5) |
501.7 (34.9) |
13.0*⇑ | 456.3 (22.7) |
464.8 (34.0) |
0.5 |
| Daily Protein Intake (gm) | 96.9 (4.0) |
99.6 (7.1) |
0.9 | 97.8 (3.1) |
87.1 (5.7) |
14.2*⇓ |
| Daily Protein – % Total Intake | 12.0 (0.2) |
11.2 (0.4) |
8.4*⇓ | 12.1 (0.4) |
10.9 (0.4) |
18.1*⇓ |
| Change in Body Weight (kg)c | −0.2 (0.5) |
1.0 (0.4) |
2.7 df = (1,18) |
−0.4 (0.7) |
−0.1 (0.3) |
0.2 df = (1,18) |
| HSQ Thirst | 38.3 (6.8) |
51.7 (6.6) |
14.7*⇑ | 46.3 (5.6) |
58.1 (5.9) |
11.5*⇑ |
| HSQ Dry Mouth | 29.5 (7.6) |
51.6 (9.6) |
36.0*⇑ | 34.1 (9.3) |
50.7 (8.9) |
20.1*⇑ |
| FDQ Savoury | 0.8 (0.2) |
1.1 (0.3) |
26.5*⇑ | 0.7 (0.2) |
1.1 (0.3) |
49.5*⇑ |
| FDQ Sweet | 1.2 (0.3) |
1.6 (0.4) |
44.2*⇑ | 1.0 (0.3) |
1.6 (0.5) |
80.8*⇑ |
| FDQ Carbohydrates | 1.5 (0.3) |
1.6 (0.4) |
5.5 | 1.4 (0.4) |
1.6 (0.4) |
11.7*⇑ |
| FDQ Proteins/Fats | 1.2 (0.3) |
1.4 (0.3) |
16.9*⇑ | 1.3 (0.4) |
1.3 (0.3) |
0.0 |
| FDQ Non-Alcoholic Beverages | 1.1 (0.4) |
1.4 (0.4) |
13.1*⇑ | 1.2 (0.4) |
1.5 (0.5) |
13.1*⇑ |
a
Data are means per day.
b
Degrees of freedom = (1,186) except where otherwise noted.
c
Weight change between Days 1 and 8, and Days 9 and 16.
DRON = dronabinol (10 mg QID); PBO = placebo; S.E.M = Standard Error of the Mean; df = degrees of freedom;
*
= Difference between dronabinol and placebo, p < 0.0l;
⇑
= Dronabinol increased scores;
⇓
= Dronabinol decreased scores; HSQ = Hunger and Satiety Questionnaire; FDQ = Food Desirability Questionnaire.