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. 2011 Jan 12;31(2):700–711. doi: 10.1523/JNEUROSCI.4152-10.2011

Figure 5.

Figure 5.

Tau reduction prevents hippocampal remodeling in hAPPJ9/Fyn mice. A, B, Calbindin levels in the molecular layer of the dentate gyrus were determined by immunohistochemistry (representative examples in A) and quantified by densitometry (B). Levels were significantly decreased in hAPPJ9/Fyn mice. This change was prevented by tau reduction (Tau × hAPPJ9/Fyn interaction, p < 0.001; ***p < 0.0001 by post hoc testing; n = 38–43 mice for Tau+/+ groups and 11–12 mice for Tau−/− groups; 6–9 months old). C–E, NPY levels were determined by immunohistochemistry (representative examples in C). Immunoreactivity in the molecular layer (D) and mossy fibers (E) was quantified by densitometry. Levels were not changed in hAPPJ9 or Fyn mice but were significantly increased in hAPPJ9/Fyn mice; the increase was prevented by tau reduction (Tau × hAPPJ9/Fyn interaction, p < 0.001; ***p < 0.0001 by post hoc testing; n = 43–53 mice for Tau+/+ groups and 18–20 mice for Tau−/− groups; 6–9 months old).