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. 2011 Jan 12;31(2):700–711. doi: 10.1523/JNEUROSCI.4152-10.2011

Figure 7.

Figure 7.

Tau reduction prevents epileptiform bursting in acute hippocampal slices from NTG and hAPPJ20 mice. Bicuculline (10 μm) was superfused into the bath during recording in area CA1, and resulting epileptiform discharges were quantified by CBI. A, Representative traces 5 min before and 15 min after bicuculline. Note that traces after bicuculline are plotted on a longer timescale to accommodate the prolonged response. B, Time course. C, Average CBI during minutes 15–25. Slices from hAPPJ20/Tau+/+ mice had larger epileptiform bursts than slices from NTG/Tau+/+ mice, and tau reduction markedly reduced bursting in both NTG and hAPPJ20 slices (hAPP × tau interaction, p < 0.002 by two-way ANOVA; ***p < 0.001 vs all other groups; ###p < 0.001 vs Tau+/+ groups; NTG/Tau−/− and hAPPJ20/Tau−/− were not significantly different; n = 6–8 slices from 3–4 mice per genotype).