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Examples of the reactions catalyzed by AKR1C3 and a schematic of the 3-phenoxybenzoic acid molecule. Testosterone is formed from Δ4-androstenedione and 9α,11β-PGF2 from PGD2 by AKR1C3-catalyzed reduction of the 17-carbonyl and 9-carbonyl groups, respectively. The 3-phenoxybenzoic acid molecule is an inhibitor of AKR1C3. This figure was drawn using ChemBioDraw Ultra 12.0 (CambridgeSoft)
