Figure 2.

(a) Alignment of the calcium-coordinating region in five calcium-transporting P-­type ATPases: SERCA1a from rabbit (accession No. ABW96358), Lmo0818 from L. monocytogenes (CAC98896), PacL from Synechococcus elongatus (BAA03906), LMCA1 from L. monocytogenes (Q8Y8Q5) and PMCA1 from human (P20020). Site I coordinating residues are shown in green and site II coordinating residues in blue. Completely conserved residues are indicated in bold. Residues that have lost the ability to coordinate a metal ion to their side-chain chemical group are shown in red. The numbering is according to SERCA1a. (b) SERCA1a Ca²⁺-binding pocket (PDB entry 1t5s; Sorensen et al., 2004 ▶) showing Ca²⁺-coordinating residues and structurally important residues. Colour-coding is as in (a).