TABLE 2.
N | Effect size per risk allele per year2 | 95% CI | P3 | |
Change in weight SDS | ||||
0–11 y | 2537 | 0.0027 | (0.0011, 0.0042) | 0.001 |
11–53 y | 2537 | −0.0003 | (−0.0006, 0.0000) | 0.023 |
Change in BMI SDS | ||||
2–11 y | 2465 | 0.0049 | (0.0024, 0.0074) | <0.001 |
11–53 y | 2537 | −0.0005 | (−0.0009, −0.0002) | 0.001 |
Change in height SDS | ||||
2–7 y | 2461 | 0.0065 | (0.0029, 0.0100) | <0.001 |
7–20 y | 2414 | −0.0014 | (−0.0024, 0.0004) | 0.008 |
SDS, SD scores.
Regression coefficients from the interaction term “risk-allele score × age” represent the association between risk-allele score and changes in weight, BMI, or height SDS per risk allele per year.
Statistical tests were performed by using multilevel modeling.