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. 2012 Apr 13;7(4):e34980. doi: 10.1371/journal.pone.0034980

Figure 1. Systemic bone turnover decreases with age.

Figure 1

Serum was collected from baseline control (non-loaded) mice of four different ages, and indices of bone turnover were measured by ELISA. (a) Osteocalcin, a marker of bone formation, and (b) carboxyl-terminal collagen cross-links (CTX), a marker of bone resorption, declined significantly with age. (n = 8; mean ± SD; a,b: groups with no common letters are significantly different, p<0.05).